By John P. Sundberg
Specialists from The Jackson Laboratory and all over the world supply useful suggestion on every little thing from easy methods to determine a colony to the place to head for particular mutations. Systematic method of review of Mouse Mutations comprises info on scientific images, grafting approaches, find out how to map the genes and assessment the particular organic features of the mice.
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Additional info for Systematic Approach to Evaluation of Mouse Mutations
Example text
5%. However, experimental data have shown for a long time that when a crossover occurs at some point along the chromosome, other crossovers occur less frequently than expected in its vicinity. This phenomenon, known as interference, has led several authors to propose the so-called “mapping functions” which convert recombination fractions into cM distances under different models of interference. In the mouse, interference is so strong that, for recombination fractions up to 20%, double recombinations are very rare, and cM distances equal recombination percents.
F. THE GENETIC MARKERS Several different types of genetic markers can be used to determine linkage. Molecular markers are codominantly inherited and can be typed easily. The most popular ones, those commonly used in the assignment of a new gene to a particular chromosomal region, are considered below. However, there are other types of markers that can be useful, including biochemical (also codominant) or immunological markers and a variety of molecular markers that take advantage of moderately or highly 13,14 repeated DNA sequences.
All development of colonies requires some form of management system, whether it is a few breeding pairs remembered by the mouse room technician, a paper ledger, a computer spreadsheet, or a custom-developed database system requiring a fulltime maintenance staff. The paper ledger is an excellent system for ease of data entry, flexibility of data types, and addition of random comments. It also has significant disadvantages in that it is not easy to extract the data for electronic analysis, and the data are prone to interpretive error while in the documentation system.