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By Dr. F.-A. Wiesel (auth.), Dr. H. Ågren, Dr. J.-L. Martinot, Prof. Dr. F.-A. Wiesel (eds.)

Positron Emission Tomography (PET) has been used for a decade in psychiatric examine to review nearby mind glucose metabolism, and the consequences appear to be inconsistent. even though, the inconsistency could be defined by means of transformations in tools and medical protocols. This challenge has been well-known by way of the EEC Concerted motion on puppy, that is why a different psychiatric team was once convened. Researchers with wisdom in numerous facets of puppy technique like mathematical types, cameras, mind atlas, stimulaton reviews and psychiatric learn geared up a gathering to debate standardization difficulties and the way to lessen mistakes in puppy investigations. This quantity will provide the reader wisdom in regards to the cutting-edge, outline difficulties and speak about attainable strategies. It provides feedback for strong cinical puppy perform. this sort of topic has no longer been released before.

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H. Agren, Department of Psychiatry, University Hospital, S-75185 Uppsala, Sweden J Neural Transm (1992) [Suppl] 37: 27-38 © Springer-Verlag 1992 Drug washout issues in studies of cerebral metabolism by positron emission tomography in psychiatric patients J. -L. Martinot Service Hospitalier Frederic Joliot, CEA, Orsay, and Service de psychiatrie, H6pital A. Chenevier, Creteil, France Many studies of brain glucose utilization by positron emission tomography attempt to describe the modifications of the brain activity during psychiatric diseases.

In: Greitz T, Ingvar DH, Widen L (eds) The metabolism of the human brain studied with positron emission tomography. Raven Press, New York, pp 399-409 Herholz K (1988) Non-stationary spatial filtering and accelerated curve fitting for parametric imaging with dynamic PET. Eur J Nucl Med 14: 477-484 Herholz K, Patlak CS (1987) The influence of tissue heterogeneity on results of fitting non-linear model equations to regional tracer uptake curves: with an application to compartmental models used in positron emission tomography.

Still, this kind of information is crucially needed because these patients are often the most impaired. Longitudinal studies could constitute an alternative allowing to avoid a long drug washout. If one considers that the phenomenological particularities of the illness are reflected in the regional cerebral metabolic rates for glucose, one issue is to learn whether the observed rCMRGIc variations reflect (1) the changes in phenomenology induced by the therapeutic action of medication, rather than (2) the direct non-specific pharmacological effect of the drugs on brain metabolism, or (3) both of the above, representing, for instance, a selective effect of the drug on certain brain regions suggested to be functionnally abnormal in patients not taking medication.

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