By Mark Thompson (Auth.)
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Extra info for Small Animal Medical Differential Diagnosis. A Book of Lists
Antimelanocyte antibodies found in serum of some affected dogs. Seen most commonly in Siamese cat, Belgian Tervuren, German Shepherd, collie, Rottweiler, Doberman Pinscher, Giant Schnauzer. Nasal hypopigmentation—season-associated lightening of nasal planum during winter months most common in Siberian Husky, Golden Retriever, Labrador Retriever, and Bernese Mountain Dog. Seen also in many other breeds. Acquired Hypopigmentation Postinflammatory—Discoid lupus erythematosus is the most common cause of postinflammatory nasal depigmentation.
Nystagmus Peripheral Vestibular Disease Horizontal nystagmus; fast phase toward normal side; no change with varying head position Otitis media/interna Feline idiopathic vestibular disease Canine geriatric vestibular disease Neoplasia Granuloma Trauma (iatrogenic secondary to ear cleaning) 54 PART ONE Clinical Signs Approach to Differential Diagnosis Ototoxic drugs Neuropathy (hypothyroid, cranial nerve VIII disease) Congenital (German Shepherd, English Cocker Spaniel, Doberman Pinscher, smooth-haired Fox Terrier, Siamese, Burmese, Tonkinese) Central Vestibular Disease Horizontal, vertical, or rotary nystagmus; direction may change with varying head position Trauma/hemorrhage Infectious inflammatory disease Viral (canine distemper virus, feline infectious peritonitis) Rickettsial (RMSF, ehrlichiosis) Fungal (cryptococcosis) Toxoplasmosis Neosporosis Granulomatous meningoencephalitis Neoplasia Vascular infarct Thiamine deficiency Metronidazole toxicity Toxic (lead, hexachlorophene) Degenerative diseases (storage diseases, neuronopathies, demyelinating diseases) Hydrocephalus Anomaly (caudal occipital malformation syndrome in Cavalier King Charles Spaniels) Head trauma Obesity Causes Excessive feeding Malnutrition High-carbohydrate diet (especially cats) Lack of exercise Inactivity (indoor life style, middle age) Neutering?
42 PART ONE Clinical Signs Approach to Differential Diagnosis Nutritional/metabolic—deficiencies of zinc, pyridoxine, pantothenic acid, and lysine are associated with graying of hair. Dark hairs may become reddish in color with copper deficiency, hypothyroidism, hyperadrenocorticism, hyperestrogenism, hyperprogesteronism, chlorine exposure, and chronic exposure to ultraviolet light. Neoplasia associated—nasal depigmentation, leukoderma, and leukotrichia sometimes seen with epitheliotropic T cell lymphoma, basal cell tumors, mammary adenocarcinoma, and gastric carcinomas.