By Dianne B. McKay (auth.), Dianne B. McKay, Steven M. Steinberg (eds.)
Kidney Transplantation: A consultant to the Care of Kidney Transplant Recipients is a straightforward to learn, brand new, scientific source written through specialists within the box of kidney transplantation. The booklet explains how donors and recipients are chosen for transplantation, how the surgery is played, and the way the specialists realize and deal with rejection. This consultant to the care of the kidney transplant recipient goals to supply sensible instructions for administration of the post-transplant recipient and is concentrated to group nephrologists and normal internists who deal with the sufferer with a kidney transplant.
Dianne B. McKay, MD, is affiliate Professor on the Scripps examine Institute, l. a. Jolla, California.
Steven M. Steinberg, MD, is affiliated with the pointy Memorial health facility, San Diego, California.
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Normal pathologists see many biopsies from transplanted organs yet few are in sufficiently big centres in order that this kinds the majority in their paintings. The e-book describes the adjustments which might be saw in transplantation in the entire significant organ platforms which are in many instances transplanted and there are money owed of the pathology of infections and of the immunological problems which are confronted through those sufferers.
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Additional info for Kidney Transplantation: A Guide to the Care of Kidney Transplant Recipients
Nierentransplantation. Berlin Klin Wochenschr 1910; 47: 573. 12. Carrel A. The transplantation of organs. NY Med J 1914; 99: 839. 13. Voronoy Y. Sobre et bloqueo del aparato reticuloendotelial del hombre en algunas formas de intodicacion por el sublimado y sobre la transplacion del rinon cadaverico como metodo de tratamiento de al unuria consecutiva a aquella intodicacion. El Siglio Med 1936; 97: 296. 14. Hamilton DNH, Reid WA. Yu Yu Voronoy and the first human kidney allograft. Surg Gynecol Obstet 1984; 159: 289.
The immunologic events relevant to solid organ transplantation are described in a temporal manner sequentially following the processes of donor harvest, anastomosis of the donor and recipient vessels, and the recipient immune response to the transplanted organ. Long-term immunologic responses that correlate with chronic rejection are also described, as is the concept of immunologic tolerance. Illustrations are provided that correlate with the processes described in the text. B. B. M. B. McKay et al.
B. McKay et al. The HLA molecules are highly polymorphic, allowing presentation of a diverse number of “foreign” peptides. The foreign peptides are derived from the allograft. Each cell simultaneously expresses many different HLA molecule/foreign peptide complexes, which provide great complexity to the system. As described in Chapter 4, two kinds of HLA molecules are important in transplantation, HLA class I and class II molecules. HLA class I molecules can be found on all nucleated cells in the body, whereas HLA class II molecules are found on antigen-presenting cells (such as dendritic cells, macrophages, B cells, endothelial cells, and even some epithelial cells).