By Peter Greaves
The new 4th variation of Histopathology of Preclinical Toxicity reviews is now thoroughly in complete colour and keeps to explain the pathology present in drug protection stories in laboratory animals with an evidence-based dialogue of the relevance of those findings to the medical research of latest medicines for people. equipped in response to organ structures, this revision includes a completely up-to-date bibliography and discusses new drug-induced pathologies and appropriate species comparisons to assist within the preclinical security evaluation of latest medications. This up-to-date reference is vital for these inquisitive about drug defense assessment, together with pathologists, toxicologists and pharmacologists operating in company, govt, educational and examine settings.
- This variation is in complete colour and contours approximately 2 hundred fine quality images
- Provides prolonged remark at the relevance of pathological findings and lines a completely up-to-date bibliography containing resources for extra reading
- Includes new content material assurance at the normal transgenic animal versions which are utilized in safeguard evaluation, particular tumor varieties brought about through medicinal drugs in rodents, and new drug-induced pathologies and lesions
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Additional info for Histopathology of Preclinical Toxicity Studies
STP/ARP/AFIP, Washington, DC. F. V. (1977): Prediction of skin irritancy sensitizing potential by testing with animals and man. A. Drill and P. Lazar (Eds), Cutaneous Toxicity, pp. 155– 173. Academic Press, New York. H. and MATTER, B. (1978): Toxicologic considerations. In: B. O. Schild (Eds), Ergot Alkaloids and Related Compounds. Handbook of Experimental Pharmacology, Vol. 49, Ch. 12, pp. 805–851. Springer-Verlag, Berlin. GROSS, P. (1982): Man-made vitreous fibers: Present status of research on health effects.
Nevertheless, the rapid development of sarcomas in response to subcutaneous implantation of microchips in heterogygous p53+/– transgenic mice suggests that different animal species and strains have the potential to respond differently to implantation of similar materials. The established sarcomas, which follow injection or implantation of a variety of different agents, have usually been classified as fibrosarcomas of variable differentiation or simply as spindle cell or pleomorphic sarcomas. , 1976).
1966): Early changes at the site of repeated subcutaneous injections of food colorings. , 4, 269–282. GRASSO, P. and GOLDBERG, L. (1966): Subcutaneous sarcoma as an index of carcinogenic potency. , 4, 297–320. GREAVES, P. (1989): Fibrous histiocytoma, malignant, subcutis, rat. C. , U. D. Hunt (Eds), Integument and Mammary Glands, Monographs on Pathology of Laboratory Animals, pp. 106–112. Springer-Verlag, Berlin. GREAVES, P. (1997): Soft tissue tumors including cardiovascular lesions. In: P. Bannasch and W.