By M. Verstraete M. D. (Leuven), F.R.C.P. (Edin.), F. A. C. P. (Hon.) (auth.)
clinical efficacy of haemostatic brokers needed to be released paintings and needed to fulftl lots of the following minimal specifications: (1) Quantitation ofthe measured blood loss was once required, and never in basic terms a scientific effect of the volume of blood misplaced, if the record pertained to a deliberate yet «open» scientific trial. (2) purely double-blind trials with random allocation of the placebo and experimental drug to preselected sufferers have been thought of appropriate for dialogue, if the blood loss had no longer been quantitated in a potential trial. (3) Defmition and acceptable choice of sufferers admitted to the trial: all inclusion and exclusion standards used to pick sufferers needed to be pointed out intimately. (4) as soon as integrated within the trial, sufferers should be withdrawn merely at the foundation of strict standards for withdrawal which were outlined upfront. (5) A double-blind trial needed to be persisted for an enough size of time if the haemostatic agent was once being assessed within the prevention of bleeding in sufferers with an enduring bleeding disease . (6) a transparent and distinctive statistical research of the implications used to be required. in addition, a transparent contrast among the healing and prophylactic worth of the haemostatic agent needed to be made and utilized individually to the crowd of sufferers with none significant uncomplicated affliction and people with a bleeding sickness e.g. : persistent thrombocytopenia, haemophilia, Rendu-Osler telangiectasia ... basic statements now not substantiated by means of experimental info, even if issued by means of recognized experts, weren't thought of an inexpensive foundation for discussion.
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Extra info for Haemostatic Drugs: A critical appraisal
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1924) Pectin and its hemostatic effects. c'R. Acad. Med. 92, 1097. VIOLLE H. and DE SAINT-RAT L. (1925) The hemostatic properties ofpectin. c'R. Acad. Sei. (Paris) 180, 603. Report on naftazone 1 Chemistry N aftazone is 1,2-naphthoquinone 2-semicarbazone. This compound, which was introduced by Derouaux (1961) is prepared by diazotization of sulphanilic acid with beta-naphthol; it is similar to adrenochrome which is also prepared in the stable monosemicarbazide form. Haemostatic action The haemostatic action of naftazone appears very similar to that of adrenochrome.
It is regrettable that such an interesting observation has not been reported and analysed in greater detail. Menorrhagia. Three weIl conducted dinical trials are available on the effect of ethamsylate in the control of menorrhagia. In a pilot study in general practice (Jaffe and Wickham, 1973) using a double-blind cross-over technique, 26 patients with heavy menstrual bleeding were treated with ethamsylate (250 mg tablets, six times a day) or identical placebo tablets during four consecutive periods.
59, 1653. RABY C. and COUPlER J. (1965) Nouvel hemostatique et antihemorragique de synthese. R. Xe Congr. Soc. Int. Transfusion Sanguine, Stockholm, 1964. Vol. 5, pp. 1 - 7, Karger, Basel. , SYKES P. and ÜUVANT J. M. (1977) Multi-centre trial of Dicynene in dental surgery. Submitted for publication. P. M. (1975) The effect of Dicynene on blood loss during and after transurethral resection of the prostate. Brit. J. Urol. 47,203. , DAEMS L. and VAN HOOF A. (1977) Double-blind trials with ethamsylate, Batroxobin or tranexamic acid on blood loss after adenotonsillectomy.