By Earl Usdin, Menek Goldstein, Arnold Friedhoff, Anastasios Georgotas (eds.)
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1982). Noradrenergic and serotonergic fibers innervate complementary layers in monkey primary visual cortex: An immunohistochemical study. Acad. , Manier, D. , Janowsky, A. , Steranka, L. R. and Sulser, F. (1982). Role of aminergic neuronal input in the down-regulation by desipramine (DMI) of the norepinephrine (NE) receptor coupled adenylate cyclase system in rat cortex. , 8: 659 Pandey, G. N. and Davis, J. M. (1981). Treatment with antidepressants, sensitivity of 8-adrenergic receptors and affective illness.
1975). Rapid changes in rat pineal a-adrenergic receptor : Alterations in 1-[3HJalprenolol binding and adenylate cyclase. Proc. Natl . Acad. Sci. M. and Costa, E. (1980). Down regulation of dihydroalprenolol and imipramine binding sites in brain of rats repeatedly treated with imipramine. Eur. J. Pharmacol. 67:289-294 Koski, G. and Klee, W. (1981). Opiates inhibit adenylate cyclase by stimulating GTP hydrolysis. Proc. Natl. Acad. Sci. , Parenti, M. H. (1981). Simultaneous determination of femtomole quantities of 5-hydroxytryptophan, serotonin and 5-hydroxyindoleacetic acid in brain using HPLC with electrochemical detection.
Such interactions may determine the type of adaptive change taking place at 5-HT receptors upon chronic antidepressant treatment. l Depar t ment s of Histology and Pharmacology, Karolinska Inst itutet , Stockholm, 2Sweden Department of Human Physiology and Endocrinology, University of Modena, Modena, Italy iAstra Research Laboratories, Sodertalje, Sweden The Hormone Laboratory, Department of Obstetrics and Gynaecology, Karolinska Hospital, Stockholm, Sweden 33 Recent research has revealed that there exist marked heterogeneities in various central pathways using the same transmitter.