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By David J. Argyle

Determination Making in Small Animal Oncology is a realistic guide for the expanding variety of veterinarians known as upon to regard sufferers with melanoma. This case-based speedy reference leads practitioners via prognosis, therapy, and administration judgements, delivering trustworthy counsel for more advantageous administration of melanoma care. With easy-to-follow algorithms to help the reader throughout the serious pondering strategy, choice Making in Small Animal Oncology solutions the questions most frequently asked in day-by-day perform to supply the melanoma wisdom practitioners and scholars want normally perform.

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10 Effect of etiology on serum [EPO] PV PNS erythrocytosis tissue hypoxia [EPO] [O2] Renal function EMH ↓ ↑ ↑ normal normal ↓ normal* normal* normal no yes yes EMH extramedullary hematopoiesis. * may become azotemic with progression/as a consequence of erythrocytosis. • direct Coombs test, slide agglutination test, total bilirubin, urinalysis – immune-mediated hemolysis • fecal occult blood test and urinalysis – blood loss • coagulation screen – DIC – thrombocytopenia, hypofibrinogenemia, increased FDPs, prolonged PT, KCCT/ APTT, increased D-dimers • Buccal mucosal bleeding time (BMBT) – platelet function • marrow cytology, histopathology – diagnose or eliminate neoplasia, myelophthisis, myelodysplasia, myelofibrosis, marrow failure, metastatic disease • imaging – tumor diagnosis and staging – survey thoracic, skeletal and abdominal radiographs, abdominal and cardiac ultrasound, with fine needle aspiration or biopsy of suspected abnormalities Gastrointestinal Ulceration • Mast cell tumors are common in dogs (cutaneous) and cats (visceral).

Fibrovascular connective tissue proliferation through chondroid metaplasia to new bone formation Primary pulmonary neoplasia, pulmonary metastatic disease in association with primary bone tumor are most common Hepatic and UGT tumors without pulmonary metastatic disease Extrathoracic tumors Chronic inflammatory intrathoracic disease Note: GH, growth hormone; UGT, urogenital tract. Differential Diagnosis Osteoarthritis Osteomyelitis Primary bone tumor Hypertrophic osteodystrophy Panosteitis Hypervitaminosis A (cat) Musopolysaccharidosis (cat) Clinical Signs Diagnostic Tests Management Nonedematous, symmetrical, extremity soft tissue: • Swelling • Pain • Heat • Tightness of the skin • Lameness • Immobility Clinical signs and radiographic assessment.

Mitotic rate, tissue architecture, and pleomorphism). This should not be confused with tumor stage, which refers to the clinical extent of disease. Determining the Type of Tumor This requires the collection and microscopic examination of cells (cytology) or tissues (histology) from a tumor using a biopsy procedure (see next section). 45 46 Decision Making in Small Animal Oncology Tumor Staging Tumors are staged according to internationally accepted sets of rules, mostly developed by the World Health Organization (WHO), which give an alphanumeric value to a patient denoting the extent of disease.

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