By M. D. Mendenhall (auth.), Professor Peter K. Vogt Ph.D., Professor Steven I. Reed Ph.D. (eds.)
More than 10 years in the past, the invention of cyclin-dependent ki nases (Cdks) ushered in a brand new period within the figuring out of mobilephone proliferation and its regulate. not just have been either one of the recognized cellphone cycle transitions, from G 1 to S part and G2 to M section, discovered to be depending on those protein kinases, however the reg ulatory assumption intrinsic to cyclin-dependent kinases, a reliable inactive catalytic subunit (the Cdk) and an volatile needful confident regulatory activating subunit (the cyclin), resulted in an easy version for phone cycle keep watch over. Modulation of cyclin accumulation, and thereby Cdk activation, was once proposed to be the overarching precept governing the passage via phone cycle levels. An different truth to emerge from the invention of Cdks was once the ex ceptional measure of evolutionary conservation maintained within the equipment and association of proliferation keep an eye on. not just have been Cdks proven to be structurally conserved among yeast and guy, yet mammalian Cdks may alternative functionally for the endogenous enzymes in a yeast mobilephone. the matter of mobilephone cycle regulate used to be notion to were almost solved. the resultant years have supplied a way more complicated view of mobile cycle regulate and the position and law of Cdks. The uncritical enthusiasm with which a number of the rules have been em braced has required tempering. for instance, even if Cdks seem to be hugely conserved phylogenetically, cyclins are less so.
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Additional resources for Cyclin Dependent Kinase (CDK) Inhibitors
Cell 50:927-935 Mendenhall MD, AI-jumaily W. Nugroho TT (1995) The Cdc28 inhibitor p40 S ' d In: Meijer L. Guidet S, Tung HYL (cds) Progress in cell cycle research. vol I. Plenum. New York Moreno S, Nurse P (1994) Regulation of progression through the G, phase of the cell cycle by the rum I ' gene. Nature 367:236-242 Morishita T. Mitsuzawa H, Nakafuku M. Nakamura S. Hattori S. Anraku Y (1995) Requirement of Saccharomyces cerevisiae Ras for completion of mitosis. Science 270:1213-1215 Muzi-Falconi M, Brown GW, Kelly TJ (1996) cdcl8+ regulates initiation of DNA replication in Schizosaccharomyces pombe.
1996; HENGST and REED 1996). It remains to be determined whether regulation of p27 translation efficiency is achieved at the level of nuclear cytoplasmic export of p27 mRNA or at the level of translational initiation. In addition to translational control, regulation at the level of degradation by the ubiquitin/proteasome pathway plays a key role in establishing p27 levels. 34 L. 1. Reed Compared with proliferating cells, the level of p27 ubiquitination is decreased in quiescent cells (PAGANO et al.
Okayama H (1994) A B-type cyC\in negatively regulates conjugation via interacting with cell cycle 'start' genes in fission yeast. EMBO J 13:1863-1872 Ogawa N, Noguchi K-i, Yamashita y, Yasuhara T, Hayashi N, Yoshida K. Oshima Y (1993) Promoter analysis of the PH081 gene encoding a 134 kDa protein bearing ankyrin repeats in the phosphatase regulon of Saccharomyces cerevisiae. Mol Gen Genet 238:444-454 Ogawa N, Noguchi K-i, Sawai H, Yamashita Y, Yompakdee C, Oshima Y (1995) Functional domains of Ph081 p, an inhibitor of Pho85p protein kinase, in the transduction pathway of P; signals in Saccharomyces cerevisiae.