By Elizabeth Fiona McInnes BVSc MRCVS PhD FRCPath
Background Lesions in Laboratory Animals should be a useful reduction to pathologists wanting to acknowledge historical past and incidental lesions whereas studying slides taken from laboratory animals in acute and persistent toxicity experiences, or whereas interpreting unique species in a diagnostic laboratory. It offers transparent descriptions and illustrations of nearly all of history lesions more likely to be encountered. some of the lesions coated are strange and will be unsuitable for treatment-related findings in preclinical toxicity studies.
The Atlas has been ready with contributions from skilled toxicological pathologists who're experts in all of the laboratory animal species lined and who've released broadly in those areas.
- over six hundred high-definition, greatest colour photos of history lesions present in rats, mice, canine, minipigs, non-human primates, hamsters, guinea pigs and rabbits
- a separate bankruptcy on lesions within the reproductive structures of all laboratory animals written via Dr Dianne Creasy, an international professional on testicular lesions in laboratory animals
- a bankruptcy on universal artifacts that could be saw in histological glass slides
- extensive references to every lesion described
- aging lesions encountered in all laboratory animal species, relatively in rats in mice that are used for carcinogenicity studies
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Extra resources for Background Lesions in Laboratory Animals. A Color Atlas
68 Hepatocytes in the submucosa of the nonglandular rat stomach. ×200. 66 Cystic degeneration of the rat liver. ×100. Intracytoplasmic, eosinophilic, inclusion bodies (Fig. 67) may develop spontaneously in rat hepatocytes (Detilleux et al 1995). Hepatocyte vacuolation is a common background change in rats which are not exsanguinated at necropsy and where there is a delay between death and removal of the liver. Histologically, the affected hepatocytes contain a single cytoplasmic vacuole filled Hemopoiesis in the liver is normal in the fetal rat liver, but occurs only under pathological con ditions in the adult rat (Detilleux et al 1995).
122). 123 Sciatic nerve demyelination in the rat. ×200. 34 BACKGROUND LESIONS IN LABORATORY ANIMALS Epidermoid cysts (Fig. 124) originate from embryological remnants of ectoderm and are made up of keratin-filled cysts lined by squamous epithelium (McMartin et al 1997). Epidermoid cysts are found occasionally on the surface of the spinal cord or the brain. Brain mineralization (Fig. 125) is occasionally encountered in the brains of older animals, especially in the thalamus (Burek 1978). Spontaneous globoid mineralization has been noted in the cerebellum of rats (Yanai et al, 1993).
37). In addition, ossification of the cartilage in the larynx is also occasionally noted in aging rats (Fig. 38). 40). Foci of minimal, generally mononuclear cell inflammation may be noted below the pleura in the rat lung (Fig. 41). 39 Mineralization of mucus within a bronchiole in the rat lung. ×100. 36b Dilated submucosal glands and eosinaphilic crystals in the larynx of the rat. ×200. 40 Mineralization of mucus within the lumen of the nasal turbinates of the rat. ×100. 34 A hair embolus within an artery in the rat lung, surrounded by inflammatory cells.