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By F Benedetti; Christoph Stein; et al

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Pain 111:1–2 Brock JA, McLachlan EM, Belmonte C (1998) Tetrodotoxin-resistant impulses in single nociceptor nerve terminals in guinea-pig cornea. J Physiol 512:211–217 Campbell JN, Meyer RA (2005) Neuropathic pain: from the nociceptor to the patient. In: Merskey H, Loeser JD, Dubner R (eds) The paths of pain 1975–2005. -G. Schaible Carlton SM, Coggeshall RE (2002) Inflammation-induced up-regulation of neurokinin 1 receptors in rat glabrous skin. Neurosci Lett 326:29–36 Carlton SM, Du J, Zhou S, Coggeshall RE (2001) Tonic control of peripheral cutaneous nociceptors by somatostatin receptors.

In Vitro . . . . . . . . . In Vivo . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 3 Opioid Receptor Ligands and Sites of Action . Endogenous Ligands . . . . . . . Exogenous Ligands . . . . . . . . Sites of Action . . .

Exogenous Ligands . . . . . . . . Sites of Action . . . . . . . . . Supraspinal and Spinal Sites . . . . . Peripheral Sites . . . . . . . . . Peripheral Opioid Receptors and Inflammation . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 3 Clinical Applications . . Acute Pain . . . . . Chronic Pain . . . . Pharmacokinetics . .

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