By V. I. Ivanov, N. A. Liapunova (auth.), Professor Dr. Günter Obe (eds.)
Utilized genetic learn, genetic toxicology and mutation examine examine the mutagenicity and cancerogenicity of chemical substances and different brokers. everlasting mutation in genes and chromosomes, should be brought on through aplethora of brokers, together with ionizing and nonionizing radiations, chemical compounds, and viruses. one of the facets discused via Advances in Mutagenesis study are (1) the certainty of the molecular mechanisms resulting in mutations, and (2) the prevention of a inconsiderate creation of mutagenic brokers into the surroundings. Contents: Nikolay W. Timofeeff-Ressovsky (1900-1981): An Essay on his existence and clinical Achievements. - Arylnitrenium Ions and the Genotoxic efficiency of fragrant Amines and Nitro Compounds. - Analysisof Mutagenicity and Chemical constitution in a variety of sequence of comparable Compounds. - Formation of 8-Hydroxyguanine by means of Oxidative DNA harm, its fix and its Mutagenic results. - Exploring Genetic and Non-Genetic Relationships: The Induction of Micronuclei. - Mechanisms of prompted Mutagenesis via Ultraviolet gentle in Escherichia coli. - Polytene Chromosomes in Mutagenesis. Three-Way Differential Stainingof Chromosomes for the identity of SCEs in keeping with mobilephone Cycle: basics and functions. - The Mammalian Centromere: Centromere Separation, Kinetochore Proteins and Aneuploidy. - Chorionic Villi research. - ExploringGenetic and Non-Genetic Relationships: The Induction of Micronuclei.
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A study on the mechanism of the genotoxicity of heterocyclic arylamines and nitroarenes. Mutagenesis 3:147-152 Dirr A, FaJ3hauer I, Wild D, Henschler D (1989) The DNA-adducts of the food mutagen and carcinogen IQ (2-amino-3-methylimidazo[4,5-fJquinoline). Arch Toxicol (Suppl) 13:224-226 EI-Bayoumi K, Lavoie El, Hecht SS, Fow EA, Hoffmann D (1981) The influence of methyl substitution on the mutagenicity of nitronaphthalenes and nitrobiphenyls. Mutat Res 81:143-153 El-Bayoumi K, Delclos KB, Heflich RH, Walker R, Shiue G-H, Hecht SS (1989) Mutagenicity, metabolism and DNA adduct formation of 6-nitrochrysene in Salmonella typhimurium.
References . . . . . . . . . . . . . . . . . . . . . . . . . 31 32 34 40 42 43 1 Introduction In 1982 the analysis of DNA ad ducts was carried out, particularly guanine ad ducts, as one approach to the identification of direct-acting mutagens present in broiled foods and environmental materials. On analysis of adduct formation by heated glucose, as a model of broiled foods, glyoxal-Gua and 8-hydroxy-Gua (oh BGua)l adducts were detected as major products (Kasai, et al.
Possible reasons for this decrease are that the oh 8 Gua glycosylase and AP endonuclease activities reside in two independent protein moieties, and are separated by fractionations. In the experiment using a crude 40 H. Kasai and S. Nishimura E. coli fraction, two bands appeared on PAGE analysis (Fig. 6, lane 14). However, the upper band, which corresponds to that obtained with the mammalian enzyme, disappeared during purification of ohBGua endonuclease. Possibly, this upper band is produced by removal of the 3' phosphate group by the 3'-phosphatase activity of E.