By Sandra Smith, Geralyn Frandsen
This renowned center nursing pharmacology textbook presents designated insurance of nursing interventions for drug treatment with similar rationales. hugely praised for its geared up and readable presentation, the textual content explains the "why" in the back of every one nursing motion, and emphasizes how medicines paintings otherwise in several sufferers. The tenth variation has a brand new clean layout and strategy with an extra concentrate on sufferer defense built-in into the textual content.
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Extra info for Abrams' Clinical Drug Therapy: Rationales for Nursing Practice (10th Edition)
Metabolism also can be decreased or delayed in a process called enzyme inhibition, which most often occurs with concurrent administration of two or more drugs that compete for the same metabolizing enzymes. indd 21 Basic Concepts and Processes 21 slowly metabolized drug may be needed to avoid adverse effects and toxicity from drug accumulation. Enzyme inhibition occurs within hours or days of starting an inhibiting agent. , 1A, 2C, 2D, 3A) and can greatly decrease drug metabolism. The rate of drug metabolism also is reduced in infants (their hepatic enzyme system is immature), in people with impaired blood flow to the liver or severe hepatic or cardiovascular disease, and in people who are malnourished or on low-protein diets.
Purines, pyrimidines) and that can be incorporated into cellular constituents, such as nucleic acids, which interfere with normal cell functioning. Several anticancer drugs act by this mechanism. 6 Cell membrane contains receptors for physiologic substances such as hormones (H) and neurotransmitters (NT). These substances stimulate or inhibit cellular function. Drug molecules (Da and Db) also interact with receptors to stimulate or inhibit cellular function. indd 23 Variables that Aﬀect Drug Actions Historically, expected responses to drugs were based on those occurring when a particular drug was given to healthy adult men (18–65 years of age) of average weight (150 lb [70 kg]).
Cohen, M. R. (2010). Shaping systems for better behavioral choices: Lessons learned from a fatal medication error. Joint Commission Journal on Quality and Patient Safety/Joint Commission Resources, 36(4), 152–163. indd 15 Introduction to Pharmacology 15 The Joint Commission. (2011). National patient safety goals. S. Food and Drug Administration. Frequently asked questions. fda. html 12/10/2012 3:08:15 PM 2 Basic Concepts and Processes LEARNING OBJECTIVES After studying this chapter, you should be able to: 1 Discuss cellular physiology in relation to drug therapy.