Download 5-HT4 Receptors in the Brain and Periphery by Robin D. Clark (auth.), Richard M. Eglen Ph.D. (eds.) PDF

By Robin D. Clark (auth.), Richard M. Eglen Ph.D. (eds.)

This e-book presents a entire, updated assessment of the distribution, pharmacology and body structure of critical 5-hydroxytryptamine (5-HT)4 receptors. The 5-HT receptor subtypes express a different pharmacology, distribution and serve as, of which the 5-HT4 receptor has been essentially the most intensively studied lately, either from a easy learn point of view and as a objective for novel therapeutics.

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85. Buchheit KH, Klein F, Kloppner E et al. The serotonin 5-HT4 receptor: Part 3: Design and pharmacological evaluation of a new class of antagonists. Bioorg Med Chern Lett 1995; 5:2495-2500. 86. Oxford AW. Substituted phenylcarbamates and phenylureas, their preparation and their use as 5-HT antagonists. lnt Pat Appl 1993; wo 93/20071. 87. Soulier JL, Yang D, Bremont Bet al. Arylcarbamate derivatives oftpiperidineethanol as potent ligands for 5-HT4 receptors. J Med Chern 1997; 40:1755-1761. 88.

Pharmacological studies on mosapride citrate (AS-4370), a gastroprokinetic agent. (1). Comparison with cisapride and metoclopramide. Yakuri to Chiryo 1993; 21:3013-3028. Chern Abst 120:95340 (1997). 56. Matsuyama S, Sakiyama H, Nei K. Identification of putative 5-hydroxytryptamine4 (5-HT 4 ) receptors in guinea pig stomach: the effect of TKS159, a novel agonist, on gastric motility and acetylcholine release. J Pharmacal Exp Ther 1996; 276:989-995. 57· Eglen RM, Bonhaus DW, Johnson LG et al. Pharmacological characterization of two novel and potent 5- HT 4 receptor agonists, RS 67333 and RS 67506, in vitro and in vivo.

GR125487: a 5-HT4 receptor antagonist with a long duration of action in vivo. Br J Pharmacol1994; 113:119P. 74· King DF, Gaster LM, Mulholland KR. 5-HT4 receptor antagonists. lnt Pat Appl1994; WO 94/27987. 75· Parker SG, HamburgerS, Taylor EM et al. SB203186, a potent 5-HT4 receptor antagonist, in porcine sinoatrial and human and porcine atriuim. Br J Pharmacol1993; 1o8:68P. 76. Wyman PA, Gaster LM, King FD et al. Azabicyclo indole esters as potent 5-HT4 receptor antagonists. Bioor Med Chern 1996; 4:255-261.

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