
By Robin D. Clark (auth.), Richard M. Eglen Ph.D. (eds.)
This e-book presents a entire, updated assessment of the distribution, pharmacology and body structure of critical 5-hydroxytryptamine (5-HT)4 receptors. The 5-HT receptor subtypes express a different pharmacology, distribution and serve as, of which the 5-HT4 receptor has been essentially the most intensively studied lately, either from a easy learn point of view and as a objective for novel therapeutics.
Read or Download 5-HT4 Receptors in the Brain and Periphery PDF
Similar nonfiction_9 books
Transplantation Pathology: A Guide for Practicing Pathologists
Normal pathologists see many biopsies from transplanted organs yet few are in big enough centres in order that this types the majority in their paintings. The publication describes the alterations that are saw in transplantation in all the significant organ platforms which are sometimes transplanted and there are bills of the pathology of infections and of the immunological problems which are confronted by way of those sufferers.
The coupling of organic and digital platforms has some time past few years emerged as a box of accelerating significance. Achievements just like the cardiac pacemaker have prepared the ground for extra subtle ways, corresponding to the lab-on-a-chip and DNA desktops. This booklet offers experiences on the most promising initiatives during this interdisciplinary study box, masking issues from bioinformatics to biosensor know-how.
Biology of the Antarctic Seas XI
Concerning the ProductPublished via the yank Geophysical Union as a part of the Antarctic study sequence. content material:
Drops and Bubbles in Contact with Solid Surfaces
The 3rd quantity in a sequence devoted to colloids and interfaces, Drops and Bubbles in touch with strong Surfaces provides an up to date evaluate of the basics and functions of drops and bubbles and their interplay with good surfaces. The chapters disguise the theoretical and experimental facets of wetting and wettability, liquid–solid interfacial houses, and spreading dynamics on diverse surfaces, together with a unique part on polymers.
- Myogenesis: Methods and Protocols
- Material Cycling of Wetland Soils Driven by Freeze-Thaw Effects
- Cerebral Blood Flow, Metabolism, and Head Trauma: The Pathotrajectory of Traumatic Brain Injury
- Many Faces of Love
- Quantum Optics, Third, revised and extended edition
- North American Parasitic Zoonoses
Additional resources for 5-HT4 Receptors in the Brain and Periphery
Example text
85. Buchheit KH, Klein F, Kloppner E et al. The serotonin 5-HT4 receptor: Part 3: Design and pharmacological evaluation of a new class of antagonists. Bioorg Med Chern Lett 1995; 5:2495-2500. 86. Oxford AW. Substituted phenylcarbamates and phenylureas, their preparation and their use as 5-HT antagonists. lnt Pat Appl 1993; wo 93/20071. 87. Soulier JL, Yang D, Bremont Bet al. Arylcarbamate derivatives oftpiperidineethanol as potent ligands for 5-HT4 receptors. J Med Chern 1997; 40:1755-1761. 88.
Pharmacological studies on mosapride citrate (AS-4370), a gastroprokinetic agent. (1). Comparison with cisapride and metoclopramide. Yakuri to Chiryo 1993; 21:3013-3028. Chern Abst 120:95340 (1997). 56. Matsuyama S, Sakiyama H, Nei K. Identification of putative 5-hydroxytryptamine4 (5-HT 4 ) receptors in guinea pig stomach: the effect of TKS159, a novel agonist, on gastric motility and acetylcholine release. J Pharmacal Exp Ther 1996; 276:989-995. 57· Eglen RM, Bonhaus DW, Johnson LG et al. Pharmacological characterization of two novel and potent 5- HT 4 receptor agonists, RS 67333 and RS 67506, in vitro and in vivo.
GR125487: a 5-HT4 receptor antagonist with a long duration of action in vivo. Br J Pharmacol1994; 113:119P. 74· King DF, Gaster LM, Mulholland KR. 5-HT4 receptor antagonists. lnt Pat Appl1994; WO 94/27987. 75· Parker SG, HamburgerS, Taylor EM et al. SB203186, a potent 5-HT4 receptor antagonist, in porcine sinoatrial and human and porcine atriuim. Br J Pharmacol1993; 1o8:68P. 76. Wyman PA, Gaster LM, King FD et al. Azabicyclo indole esters as potent 5-HT4 receptor antagonists. Bioor Med Chern 1996; 4:255-261.